Histogen Aesthetics believes there is nothing more natural than what your skin cells already produce. ReGenica contains naturally occurring, embryonic-like human proteins and growth factors which help soothe, rejuvenate and revitalize skin.

This advanced skin rejuvenation system consists of three individual products designed to work together to help restore your skin to a healthier, more youthful appearance.

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The cornerstone ingredient behind the Histogen Aesthetics rejuvenation system is ReGenicaTM. This proprietary complex is created by growing newborn fibroblasts, which are safe and non-controversial, in a simulated embryonic environment, and then harvesting the naturally secreted proteins, growth factors and other synergistic bioproducts that are produced.

ReGenica contains a diverse mixture of actives, including human growth factors such as Keratinocyte Growth Factor, soluble human ECM proteins such as collagen, and embryonic proteins which support the epidermal stem cells that renew skin throughout life.
ReGenica formulations are designed for optimal skin absorption, stimulating your own skin cells (keratinocytes and fibroblasts) to reinvigorate collagen and protein synthesis resulting in rejuvenated skin.

ReGenica Facial Rejuvenation Post Laser Complex
ReGenica Facial Rejuvenation Complex is designed to help restore moisture and promote healing of damaged skin following procedures such as phototherapeutic laser, dermabrasion or chemical peels.

Post Laser Complex

In two physician-based clinical studies, patients utilizing ReGenica had improved moisture and healing, and a more rapid recovery, following ablative and non-ablative laser treatment.

ReGenica Facial Rejuvenation Complex Post Laser Treatment

ReGenica Day and Night Rejuvenation System

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Natural embryonic-like human proteins stimulate skin cells to combat aging and help support healing

Histogen Aesthetics utilizes a proprietary manufacturing process in which newborn dermal fibroblast cells are grown on beads in controlled bioreactors that maintain an embryonic-like environment, including low oxygen and low gravity conditions. During this process, the cells secrete growth factors such as Keratinocyte Growth Factor and Vascular Endothelial Growth Factor, and soluble extracellular matrix proteins such as collagens, laminin and decorin, which are associated with skin renewal and scarless healing. In addition, factors associated with scarring, such as TGFbeta, are decreased or nonexistent.

The resulting product is ReGenica, a complex made up of the naturally produced cell signaling materials and embryonic-like proteins which support the epidermal stem cells that renew skin throughout life.

Through Histogen’s unique and proprietary technology process, Histogen Aesthetics is able to produce a skincare system that differentiates itself from other growth factor-containing skin products on the market. ReGenica:

  • does not contain any plant-derived growth factors or phytoestrogens which can be subject to seasonal variability and pesticide contamination
  • does not contain genetically-engineered growth factors (recombinant proteins)
  • does not contain fetal bovine or other animal serum, so no animal hormones are present

“Our patients undergoing cosmetics procedures are very interested in minimizing their downtime as well as minimizing their risk, and I believe the Histogen formulations do both,” said Dr. Garth Fisher, renowned plastic surgeon and primary investigator on the first ReGenica post-resurfacing clinical study. “In addition, they have the added benefit of minimizing the risks associated with allergic responses from using animal products.”

The ReGenica products are formulated based upon the results of randomized double-blind, placebo-controlled clinical studies, in which independent dermatologists both collected and blind-reviewed the data. In addition to before and after photographs, assessment of product efficacy was determined by instrumental assessment of transepidermal water loss (TEWL), viscoelasticity measurements and three dimensional image analysis of silicon replicas.

“As a participant in a ReGenica clinical study, I was impressed to see the rigorous and controlled trial process Histogen Aesthetics’ products undergo,” said Stephanie Parker, a patient in the ReGenica post-resurfacing clinical study. “I feel comfortable in knowing that any products released by the Company have been tested and proven safe and effective, and am excited that the anti-aging and post-resurfacing products will now be available. ReGenica products aren’t just making claims – I saw real results.”

Initial product launches in the ReGenica rejuvenation system include the ReGenica Facial Rejuvenation Complex for post-resurfacing, ReGenica Advanced Rejuvenation Day Repair with sunscreen and ReGenica Advanced Rejuvenation Overnight Repair. The system is now available at special introductory pricing through dermatologists, plastic surgeons and other aesthetic medicine professionals, and can also be purchased online through www.histogenaesthetics.com.

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(888) 371-7776

(310) 947-2857


Los Angeles

Mike Mansfield

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